Hepatoid Adenocarcinoma Of The Lung Metastasizing To The Gingiva

OncoTargets and Therapy

卷:Volume 12

关键词: hepatoid adenocarcinoma;    lung;    gingiva;    metastasis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Chunhua Wang,1 Guohui Xu,2 Ge Wu,2 Zhiming Chen,3 Zhiyong Sun,4 Ping Zheng,5 Yecai Huang,6 Fuqiang Wang,7 Xuegang Yang2 1Department of Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, Sichuan 610041, People’s Republic of China; 2Department of Interventional Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, Sichuan 610041, People’s Republic of China; 3PET/CT Center, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, People’s Republic of China; 4Nuclear Department, The General Hospital of Western Theater Command, Chengdu, Sichuan 610083, People’s Republic of China; 5Department of Pathology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, Sichuan 610041, People’s Republic of China; 6Department of Radiation Oncology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, Sichuan 610041, People’s Republic of China; 7Department of Interventional Radiology, Linshui County People’s Hospital, Guang’an, Sichuan 638500, People’s Republic of ChinaCorrespondence: Xuegang YangDepartment of Interventional Radiology, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Radiation Oncology Key Laboratory of Sichuan Province, No.55, Lane 4, RenMin Road (South), Chengdu, Sichuan 610041, People’s Republic of ChinaTel [phone]Email [e-mail]: Hepatoid adenocarcinoma (HAC) of the lung, a very rare tumor, has been reported metastasizing to lymph nodes and distant tissue, with poor prognosis. We report a case of lung HAC metastasizing to the gingiva, which is a rare metastasis site.Case Report: A 70-year-old, 50-pack-year, male smoker was diagnosed with a lung mass on a health examination. A chest CT showed a lung mass in the superior lobe of the right lung and enlarged lymph nodes in the right hilum and mediastinum. Liver and other digestive tumors were excluded. The lung mass was confirmed to be HAC by biopsy with positivity of HepPar-1. Despite erlotinib therapy, the tumor metastasized to the gingiva. Then, docetaxel and nedaplatin therapy, radiotherapy, and bevacizumab therapy were administered successively. The patient died of tumor progression 9 months after presentation.Conclusion: Gingival metastasis of lung HAC is rare. The patient had a poor outcome. Further studies need to be conducted on lung HAC.Keywords: hepatoid adenocarcinoma, lung, gingiva, metastasis

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