Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses

Molecules

卷:21

Waldiceu A. Verri¹  Ana C. Rossaneis¹  Miriam S. N. Hohmann¹  Victor Fattori¹  Felipe A. Pinho-Ribeiro¹ 

[1] Departamento de Ciências Patológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, Rodovia Celso Garcia Cid KM480 PR445, Caixa Postal 10.011, 86057-970 Londrina, Paraná, Brazil;

关键词: analgesia;    capsaicinoids;    chili peppers;    desensitization;    TRPV1;   

DOI  :  10.3390/molecules21070844

来源: DOAJ

【 摘 要 】

In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.

【 授权许可】

Unknown