Phenolic compounds from Syzygium jambos (Myrtaceae) exhibit distinct antioxidant and hepatoprotective activities in vivo

Journal of Functional Foods

卷:41

Ahmed Esmat¹  Ashraf B. Abdel-Naim²  Mohamed A.O. Abdelfattah²  Malak Dmirieh³  Ganna Petruk⁴  Michael Wink⁵  Daria Maria Monti⁶  Mansour Sobeh⁶ 

[1] Corresponding authors.;

[2] Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte Sant’Angelo, via Cinthia 4, 80126 Naples, Italy;

[3] Department of Chemistry, American University of the Middle East, Eqaila 54200, Kuwait;

[4] Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo 11566, Egypt;

[5] Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia;

[6] Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Heidelberg, Germany;

关键词: Syzygium jambos;    HPLC-PDA-ESI-MS/MS;    Antioxidant;    Hepatoprotective;    In vivo;    Caenorhabditis elegans;   

DOI  :  

来源: DOAJ

【 摘 要 】

HPLC-PDA-MS/MS analysis of Syzygium jambos leaf extract allowed the identification of 17 secondary metabolites, including flavonol glycosides, flavonol di-glycosides, and flavones as well as ellagitannins and phenolic acids. The extract showed promising antioxidant activities in different experimental models. In Caenorhabditis elegans, the extract mediated a dose dependent survival rate and decreased the intracellular ROS level and HSP-16.2 expression. In a rat model against acute CCl4 intoxication, the extract reduced the levels of all tested liver markers ALT, AST, TB, TC, TG, and MDA and increased GSH and SOD; effects were similar to those of silymarin. In hepatocytes, pre-treatment with the extract inhibited ROS production, against the deleterious effects of sodium arsenite, and increased GSH levels, without alteration in the phosphorylation levels of p38 and of its direct target, MAPKAPK-2. These results demonstrate the high efficacy of S. jambos extract in free radical-scavenging, and inhibition of reactive oxygen species.

【 授权许可】

Unknown