Corticomedullary shunting after ischaemia and reperfusion in the porcine kidney?

BMC Nephrology

卷:23

Bente Jespersen¹  Anna Krarup Keller¹  Michael Rehling²  Jørgen Frøkiær²  Lene Elsebeth Nielsen²  Stine Gram Skjøth²  Christian Flø² 

[1] Department of Clinical Medicine, Aarhus University;

[2] Department of Nuclear Medicine, PET-Center, Aarhus University Hospital;

关键词: Microspheres;    Renal blood flow;    Renal ischaemia;    Renal perfusion;    Renal redistribution;    Renal shunts;   

DOI  :  10.1186/s12882-022-02780-0

来源: DOAJ

【 摘 要 】

Abstract Background Renal perfusion may redistribute from cortex to medulla during systemic hypovolaemia and after renal ischaemia for other reasons, but there is no consensus on this matter. We studied renal perfusion after renal ischaemia and reperfusion. Methods Renal perfusion distribution was examined by use of 153Gadolinium-labeled microspheres (MS) after 2 h (hrs) and 4 h ischaemia of the pig kidney followed by 4 h of reperfusion. Intra-arterial injected MS are trapped in the glomeruli in renal cortex, which means that MS are not present in the medulla under normal physiological conditions. Results Visual evaluation after reperfusion demonstrated that MS redistributed from the renal cortex to the medulla in 6 out of 16 pigs (38%) subjected to 4 h ischaemia and in one out of 18 pigs subjected to 2 h ischaemia. Central renal uptake of MS covering the medullary/total renal uptake was significantly higher in kidneys subjected to 4 h ischaemia compared with pigs subjected to 2 h ischaemia (69 ± 5% vs. 63 ± 1%, p < 0.001), and also significantly higher than in the contralateral kidney (69 ± 5% vs. 63 ± 2%, p < 0.001). Analysis of blood and urine demonstrated no presence of radioactivity. Conclusion The study demonstrated the presence of MS in the renal medulla in response to renal ischaemia and reperfusion suggesting that severe ischaemia and reperfusion of the pig kidney leads to opening of functional shunts bypassing glomeruli.

【 授权许可】

Unknown