Diagnostic and prognostic value of nucleolar proteins in the regulation of tumor cells proliferation in patients with lung carcinoma and adrenocortical cancer

RUDN Journal of Medicine

卷:0

E A Smirnova¹  N T Reikhlin¹  I A Bukaeva¹  A V Filimonyuk² 

[1] Российский онкологический научный центр им. Н.Н. Блохина РАМН;

[2] Российский университет дружбы народов;

关键词: адренокортикальный рак;    пролиферативная активность;    маркеры длительности митотического цикла;    B23/нуклеофозмин;    C23/нуклеолин;    В23/nucleofozimine;   

DOI  :  

来源: DOAJ

【 摘 要 】

We studied correlation between the degree of malignancy, prognosis, survival of oncological patients, and the number of proliferating cells (Ki-67 index), the rate of cell proliferation, the continuance of the mitotic cycle (and the expression of Ag-OYAOR-proteins-В23/nucleofozimine S23/nukleoline) in 16 patients with adrenocortical carcinoma and in 20 cases of “small” lung cancer (up to 3 cm in diameter), whose tumors were removed and long-term results were evaluated. The comparative study of proliferative activity of cells in the two groups of patients with different survival period after tumor removal showed the heterogeneity of Ki-67 index, which determined the number of proliferating cells. In the first group of patients (with a good prognosis) Ki-67 index was high, and expression of Ag-OYAOR proteins was low. At the same time, in the second group of patients, whose prognosis was poor, Ki-67 index in the tumor was low, but the expression of Ag-OYAOR-protein was high. So, we can make a conclusion, that it is impossible to discuss the degree of malignancy of the tumor and the prognosis, based only on Ki-67 index. Ag-OYAOR-protein and Ki-67 index reflect different aspects of cell proliferation: the rate of cell proliferation (Ag-OYAOR expression) and the number of proliferating cells (Ki-67 index).

【 授权许可】

Unknown