Imaging Features of Multiple Myeloma Extramedullary Lesions in the Liver with 18F-FDG PET/CT, Contrast-Enhanced CT and MRI

Diagnostics

卷:9

Antonia Dimitrakopoulou-Strauss¹  Robert Hog¹  Dimitris Papamichail¹  Hartmut Goldschmidt² 

[1] Clinical Cooperation Unit Nuclear Medicine, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany;

[2] Internal Medicine V and National Center for Tumor Diseases (NCT), University Clinic Heidelberg, 69120 Heidelberg, Germany;

关键词: multiple myeloma;    extramedullary;    18f-fdg pet/ct;    mri;    contrast-enhanced ct;   

DOI  :  10.3390/diagnostics9040179

来源: DOAJ

【 摘 要 】

Ηepatic involvement in multiple myeloma is not common; nevertheless, it is associated with poorer outcome. Heterogeneous features have been described in few published reports so far. We present the imaging findings of PET/CT in comparison to those of MRI for two multiple myeloma (MM) patients, one with a liver lesion suspicious for myeloma metastasis on PET and one with multiple liver lesions suspicious for myeloma metastases on MRΙ. The subsequent ultrasound-guided needle biopsies confirmed the extramedullary spread of the disease in both patients. The first case exhibited a match in both functional imaging modalities (PET and MRI) but a mismatch of intense metabolic activity on ¹⁸F-fluorodeoxyglucose (18F-FDG) PET/CT and iso-attenuating liver parenchyma on contrast-enhanced CT. The second case showed a mismatch of signal elevation persistence on diffusion-weighted imaging (DWI) and physiologic 18F-FDG distribution in the liver parenchyma. These cases present different imaging features in MM lesions of the liver using PET/CT and MRI, reflecting the high disease heterogeneity in patients with MM and demonstrating that the use of both PET/CT and MRI may offer complementary information.

【 授权许可】

Unknown