miR-221/222 as biomarkers and targets for therapeutic intervention on cancer and other diseases: A systematic review

Molecular Therapy: Nucleic Acids

卷:27

Mariamena Arbitrio¹  Giulio Caridಠ Maria Teresa Di Martino²  Francesco Luciano²  Martina Montesano²  Katia Grillone²  Caterina Riillo²  Valentina Farenza²  Valentina Uppolo²  Federica Falcone²  Maria Anna Siciliano²  Giuseppe D'Aquino²  Natale Daniele Calandruccio²  Onofrio Cuomo²  Licia Pensabene²  Francesca Scionti²  Alessia Cordua²  Cristina Napoli²  Caterina Romeo²  Pierfrancesco Tassone²  Michele Tafuni²  Maria D'Apolito²  Pierosandro Tagliaferri³  Daniele Caracciolo⁴  Caterina Labanca⁵ 

[1] Corresponding author: Maria Teresa Di Martino, Department of Experimental and Clinical Medicine, Magna Græcia University, Catanzaro, Italy.;

[2] Department of Experimental and Clinical Medicine, Magna Græcia University, Catanzaro, Italy;

[3] Department of Surgical and Medical Sciences, Magna Græcia University, Catanzaro, Italy;

[4] Institute for Research and Biomedical Innovation (IRIB), Italian National Council (CNR), Catanzaro, Italy;

[5] Institute for Research and Biomedical Innovation (IRIB), Italian National Council (CNR), Messina, Italy;

关键词: miR-221;    miR-221/222;    miRs;    miR;    microRNA;    miR therapeutics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Among deregulated microRNAs (miRs) in human malignancies, miR-221 has been widely investigated for its oncogenic role and as a promising biomarker. Moreover, recent evidence suggests miR-221 as a fine-tuner of chronic liver injury and inflammation-related events. Available information also supports the potential of miR-221 silencing as promising therapeutic intervention. In this systematic review, we selected papers from the principal databases (PubMed, MedLine, Medscape, ASCO, ESMO) between January 2012 and December 2020, using the keywords “miR-221” and the specific keywords related to the most important hematologic and solid malignancies, and some non-malignant diseases, to define and characterize deregulated miR-221 as a valuable therapeutic target in the modern vision of molecular medicine. We found a major role of miR-221 in this view.

【 授权许可】

Unknown