Journal of the South African Veterinary Association | 卷:74 |
Toxicokinetics of cotyledoside following intravenous administration to sheep | |
关键词: Cardiac Glycoside; Cotyledoside; Kinetics; Krimpsiekte; Sheep; | |
DOI : 10.4102/jsava.v74i1.488 | |
来源: DOAJ |
【 摘 要 】
Cotyledoside, a bufadienolide cardiac glycoside, was administered intravenously to sheep in 2 studies. In experiment 1, sheep (n = 4) received 0.0135 mg / kg daily on 5 consecutive days and in the 2nd experiment, sheep (n = 4) received 0.027 mg / kg as a single dose. Jugular blood was collected at different time intervals and kinetic parameters were determined. The data fitted a 1-compartmental model. In both experiments a short half-life (t1/2) and mean residence time (MRT), a relative small volume of distribution (Vdss) and rapid clearance were calculated. In the 1st experiment, t1/2 and MRT increased significantly (P < 0.007) from Day (D) 0 to D 4. It is suggested that the rapid decline in plasma cotyledoside concentrations in sheep denotes rapid distribution of cotyledoside to the tissues or extracellular spaces and possible accumulation at the biophase.
【 授权许可】
Unknown