Mussel-inspired agarose hydrogel scaffolds for skin tissue engineering

Bioactive Materials

卷:6

Mengying Zhang¹  Yijing Huang²  Yuna Qian³  Wenhao Pan⁴  Wei Dong⁵  Qiankun Zeng⁶  Jianliang Shen⁶  Xiaoliang Qi⁷  Ting Su⁸ 

[1] Engineering Research Center of Clinical Functional Materials and Diagnosis &

[2] Materials Engineering, Fuyang Normal University, Fuyang, 236037, China;

[3] School of Chemical Engineering, Nanjing University of Science &

[4] School of Chemistry &

[5] Technology, Nanjing, 210094, China;

[6] Treatment Devices of Zhejiang Province, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, 325001, China;

[7] State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325027, China;

关键词: Hydrogel;    Agarose;    Polydopamine;    Cell adhesion;    Tissue engineering;   

DOI  :  

来源: DOAJ

【 摘 要 】

Polysaccharide hydrogels are widely used in tissue engineering because of their superior biocompatibility and low immunogenicity. However, many of these hydrogels are unrealistic for practical applications as the cost of raw materials is high, and the fabrication steps are tedious. This study focuses on the facile fabrication and optimization of agarose-polydopamine hydrogel (APG) scaffolds for skin wound healing. The first study objective was to evaluate the effects of polydopamine (PDA) on the mechanical properties, water holding capacity and cell adhesiveness of APG. We observed that APG showed decreased rigidity and increased water content with the addition of PDA. Most importantly, decreased rigidity translated into significant increase in cell adhesiveness. Next, the slow biodegradability and high biocompatibility of APG with the highest PDA content (APG3) was confirmed. In addition, APG3 promoted full-thickness skin defect healing by accelerating collagen deposition and promoting angiogenesis. Altogether, we have developed a straightforward and efficient strategy to construct functional APG scaffold for skin tissue engineering, which has translation potentials in clinical practice.

【 授权许可】

Unknown