Dark tea extracts: Chemical constituents and modulatory effect on gastrointestinal function

Biomedicine & Pharmacotherapy

卷:130

Jing-chi Zhang¹  Xiang-lan Wu¹  Chun-fang Liu¹  Dan-Ming Lu¹  Shu-xian Cai¹  Feng Miao¹  Yi-long Li¹  Hai-yan Lin¹  Zhong-hua Liu¹  Wan Zhu²  Chen-jie Zhao²  Jian Ouyang²  Jian-an Huang²  Fang Zhou²  Ming-zhi Zhu²  Qi-ye Wang²  Neng-xin Li²  Yu-xin Song²  Xin Zeng²  Zhi-ping Gong³ 

[1] Hunan Provincial Key Laboratory for Germplasm Innovation and Utilization of Crop., Hunan Agricultural University, Changsha, 410128, China;

[2] National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Key Laboratory of Tea Science of Ministry of Education, College of Horticulture, Hunan Agricultural University, Changsha, 410128, China;

[3] The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China;

关键词: Dark tea;    Gastrointestinal function;    Gastrointestinal transit;    Antibiotic;    Restoration;    Intestinal microbes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Processing of dark tea varieties, such as Fu brick tea, Liupao tea, Qianliang tea, and Qing brick tea, includes solid-state fermentation involving microorganisms. In this study, we analyzed the major chemical constituents of dark tea extracts and evaluated their modulatory effect on the gastrointestinal function in normal mice, including the improvement of gastrointestinal transit and intestinal microbial, as well as the attenuation of intestinal microbial dysbiosis and intestinal pathological damage, and the adjustment of immune function in antibiotic-treated mice. Substantial differences in major chemical constituents, including total polyphenols, total organic acids, water extract content, 18 free amino acids, gallic acid, and six tea catechins, were observed among Fu brick tea, Qianliang tea, Qing brick tea, and Liupao tea extracts. Extracts from the four dark tea varieties significantly promoted gastrointestinal transit and colonization of beneficial Bifidobacterium and Lactobacillus, and inhibited the growth of harmful Escherichia coli and Enterococcus in normal mice. In addition, Qianliang tea, Qing brick tea, and Liupao tea extracts significantly accelerated the reversal of the ampicillin sodium-induced pathological damage in the ileum, intestinal bacterial dysbiosis (Bifidobacterium, Lactobacillus, E. coli, and Enterococcus), and low immunity.

【 授权许可】

Unknown