Increased body fat mass reduces the association between fructosamine and glycated hemoglobin in obese type 2 diabetes patients

Journal of Diabetes Investigation

卷:12

Isabelle Simoneau¹  Pauline Legris¹  Bruno Vergès¹  Benjamin Bouillet¹  Alexia Rouland¹  Sabine Baillot‐Rudoni¹  Jean‐Michel Petit¹  Marie‐Claude Brindisi¹  Laurence Duvillard² 

[1] Department of Endocrinology, Diabetology and Metabolic Diseases CHU Dijon Dijon France;

[2] INSERM LNC‐UMR1231 University of Burgundy Dijon France;

关键词: Diabetes;    Fructosamine;    Obese;   

DOI  :  10.1111/jdi.13383

来源: DOAJ

【 摘 要 】

Abstract Obesity is increasing in patients with type 2 diabetes. A possible reduced association between fructosamine and glycated hemoglobin (HbA1c) in obese individuals has been previously discussed, but this has never been specifically evaluated in type 2 diabetes, and the potential influence of body fat mass and fat distribution has never been studied. We studied 112 type 2 diabetes patients with assessment of fat mass, liver fat and fat distribution. Patients with body mass index (BMI) above the median (34.9 kg/m2), versus BMI below the median, had a correlation coefficient between fructosamine and HbA1c significantly reduced (r = 0.358 vs r = 0.765). In the whole population, fructosamine was correlated negatively with BMI and fat mass. In multivariate analysis, fructosamine was associated with HbA1c (positively) and fat mass (negatively), but not with BMI, liver fat or fat distribution. The association between fructosamine and HbA1c is significantly reduced in the most obese type 2 diabetes patients, and this is mostly driven by increased fat mass.

【 授权许可】

Unknown