Induction of Tolerance and Immunity by Dendritic Cells: Mechanisms and Clinical Applications

Frontiers in Immunology

卷:10

Radek Spisek¹  Lenka Palova-Jelinkova¹  Jirina Bartunkova¹  Jitka Fucikova¹ 

[1] Department of Immunology, 2nd Faculty of Medicine and University Hospital Motol, Charles University, Prague, Czechia;

[2] Sotio, Prague, Czechia;

关键词: dendritic cells;    immunotherapy;    cancer;    autoimmune disorders;    vaccine preparation;   

DOI  :  10.3389/fimmu.2019.02393

来源: DOAJ

【 摘 要 】

Dendritic cells (DCs) are key regulators of immune responses that operate at the interface between innate and adaptive immunity, and defects in DC functions contribute to the pathogenesis of a variety of disorders. For instance, cancer evolves in the context of limited DC activity, and some autoimmune diseases are initiated by DC-dependent antigen presentation. Thus, correcting aberrant DC functions stands out as a promising therapeutic paradigm for a variety of diseases, as demonstrated by an abundant preclinical and clinical literature accumulating over the past two decades. However, the therapeutic potential of DC-targeting approaches remains to be fully exploited in the clinic. Here, we discuss the unique features of DCs that underlie the high therapeutic potential of DC-targeting strategies and critically analyze the obstacles that have prevented the full realization of this promising paradigm.

【 授权许可】

Unknown