CSF Protein Concentration Shows No Correlation With Brain Volume Measures

Frontiers in Neurology

卷:10

Thomas Korn¹  Claus Zimmer³  Jan Kirschke³  Bernhard Hemmer⁴  Viola Pongratz⁵  Sophia Grahl⁵  Alexander Wuschek⁵  Mark Mühlau⁵ 

[1] Department of Experimental Neuroimmunology, Technische Universität München, Munich, Germany;

[2] Department of Neurology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany;

[3] Department of Neuroradiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany;

[4] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany;

[5] TUM-Neuroimaging Center, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany;

关键词: albumin;    brain volume;    CSF;    protein;    MRI;   

DOI  :  10.3389/fneur.2019.00463

来源: DOAJ

【 摘 要 】

Background: CSF protein concentrations vary greatly among individuals. Accounting for brain volume may lower the variance and increase the diagnostic value of CSF protein concentrations.Objective: To determine the relation between CSF protein concentrations and brain volume.Methods: Brain volumes (total intracranial, gray matter, white matter volumes) derived from brain MRI and CSF protein concentrations (total protein, albumin, albumin CSF/serum ratio) of 29 control patients and 497 patients with clinically isolated syndrome or multiple sclerosis were studied.Finding: We found significant positive correlations of CSF protein concentrations with intracranial, gray matter, and white matter volumes. None of the correlations remained significant after correction for age and sex.Conclusion: Accounting for brain volume derived from brain MRI is unlikely to improve the diagnostic value of protein concentrations in CSF.

【 授权许可】

Unknown