Corneal Volume Measurements with Pentacam for Detection of Keratoconus and Subclinical Keratoconus

Türk Oftalmoloji Dergisi

卷:43

Sucattin İlker Kocamış¹  Hüseyin Simavlı²  Nagihan Uğurlu³  Hasan Basri Çakmak⁴  Nurullah Çağıl⁴  Şaban Şimşek⁴ 

[1] Ardahan State Hospital, Ardahan, Turkey;

[2] Bolu State Hospital, Bolu, Turkey;

[3] Yıldırım Beyazıt University Ankara Ataturk Training and Research Hospital, Ankara, Turkey;

[4] Yıldırım Beyazıt University School of Medicine, Department of Ophthalmology, Ankara, Turkey;

关键词: Corneal volume;    keratoconus;    pentacam;    subclinical keratoconus;   

DOI  :  10.4274/tjo.43.97658

来源: DOAJ

【 摘 要 】

Pur po se: To estimate the sensitivity and specificity of corneal volume (CV) measurements in discriminating keratoconus and subclinicalkeratoconus from normal corneas.Ma te ri al and Met hod: Clinical records and Pentacam measurements of ninety-four patients with keratoconus, 36 patients withsubclinical keratoconus, and 166 refractive surgery candidates with normal corneas were evaluated retrospectively. CV within 3, 5, 7, and10 mm circles around the central cornea was measured in one eye of each patient, using the Pentacam. CV measurements in keratoconus and subclinical keratoconus were compared with normal corneas. Receiver operating characteristic (ROC) curves were used to determinethe test’s overall predictive accuracy and to identify optimal CV cutoff points to maximize sensitivity and specificity in discriminatingkeratoconus and subclinical keratoconus from normal corneas.Re sults: Mean CV within a 3.0 mm circle around the central cornea was statistically lower in keratoconus (3.4±0.2 mm3, p<0.001) andsubclinical keratoconus (3.6±0.2mm3, p<0.001) versus normal corneas (3.8±0.3mm3). ROC curve analysis showed high overall predictiveaccuracy of CV for keratoconus (area under the curve 0.92). Optimal cutoff points were 3.55 mm3 for keratoconus and 3.65 mm3 forsubclinical keratoconus. These values provided sensitivity and specificity of 83% and 86%, respectively, for keratoconus, and 61% and74% for subclinical keratoconus.Dis cus si on: CV within a 3.0 mm circle around the central cornea effectively discriminates keratoconus from normal corneas. However,its sensitivity and specificity are lower for subclinical keratoconus diagnosis. (Turk J Ophthalmol 2013; 43: 77-82)

【 授权许可】

Unknown