Effects of Theta Transcranial Alternating Current Stimulation Over the Frontal Cortex on Reversal Learning

Brain Stimulation

卷:9

Paul Zerr¹  Miles Wischnewski²  Dennis J.L.G. Schutter³ 

[1] Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, The Netherlands;

[2] Corresponding author. Tel.: [phone].;

关键词: Electroencephalogram;    Reversal learning;    Theta activity;    Theta–beta ratio;    Transcranial alternating current stimulation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Theta oscillations in the electroencephalogram (EEG) are associated with learning and behavioral adaptation. Objective: To investigate the effects of theta transcranial alternating current stimulation (tACS) applied to the frontal cortex on reversal learning. Methods: Healthy volunteers participated in a sham-controlled between subjects design. TACS at 1 mA peak-to-peak was administered during a reward–punishment reversal learning task. Resting state EEG was measured before and after tACS and the task. Results: Active tACS improved learning ability, but at the same time interfered with applying the rule to optimize behavior. Furthermore, a significant decrease in frontal theta–beta EEG ratios was observed following active tACS. Conclusions: Results provide behavioral and electrophysiological evidence for influencing reversal learning with exogenous oscillatory electric field potentials applied to the frontal cortex.

【 授权许可】

Unknown