Lipases and proteases inhibition by Averrhoa carambola L. fruit extracts

Phytomedicine Plus

卷:1

Silvana Marcussi¹  Daniela Aparecida Oliveira²  Pedro Henrique Souza Cesar²  Marcus Vinicius Cardoso Trento²  Mariana Aparecida Braga³ 

[1] Biochemistry Laboratory, Department of Chemistry, Federal University of Lavras, Mailbox: 3037, Lavras, Zip Code: 37200-900, Minas Gerais, Brazil;

[2] Corresponding author.;

关键词: Medicinal plants;    Toxins as tools;    Phenolic compounds;    Phospholipases A2, Proteases;    Fruit toxicology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Proteases and phospholipases A2 are involved in processes related to hemostasis. Medicinal plants which contain bioactive phytochemicals, can act as enzymatic modulators. Method: In this study, the chemical composition and pharmacological potential exerted by the aqueous and ethanolic extracts of Averrhoa carambola L. fruits were evaluated on the activity of phospholipases and proteases present in the Bothrops, Crotalus durissus terrificus (C.d.t.), and Lachesis muta snake venoms. Results: In the extracts were identified phenolic compounds, which are possibly responsible for the inhibition of the phospholipase (20–50%), hemolytic, and fibrinogenolytic (up to 100%) activities. The aqueous extract presented a pro-coagulant activity on the C.d.t. venom and anti-coagulant on the B. atrox venom. The thrombolytic activity was inhibited (above 20%) only when induced by L. muta venom. The thrombolysis induced by the Bothrops sp. venoms was potentiated by the two extracts evaluated. Conclusions: Both extracts presented pharmacological activity modulating the activity of toxins.

【 授权许可】

Unknown