The first experience of orthotropic implantation of decellularized mitral allograft

Učenye Zapiski Sankt-Peterburgskogo Gosudarstvennogo Medicinskogo Universiteta im. Akad. I.P. Pavlova

卷:22

S. M. Yashin¹  P. P. Yablonsky² 

[1] Исследовательская лаборатория биотехнологий и искусственных органов имени Г. В. Лейбница Медицинского университета Ганновера;

[2] Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова;

关键词: сердечно-сосудистая хирургия;    протезирование митрального клапана;    децеллюляризация;    митральный аллографт;    cardio-vascular surgery;    mitral valve replacement;    decellularization;    mitral allograft;   

DOI  :  10.24884/1607-4181-2015-22-3-64-65

来源: DOAJ

【 摘 要 】

Traditional biological and mechanical valve substitutes have some well-known limitation, such as rapid deterioration of the tissue ones in young patient and the high risk of thrombosis and anticoagulation therapy complications for the mechanical ones. At the same time the aortic and pulmonary valves can already be replaced with decellularized allografts that showed promising results in terms of both hemodynamics and reliability while anticoagulation for them is not needed. This paper describes the first orthotropic implantation of the decellularized mitral valve allograft in sheep model. The original method without stabilizing ring is described, which have shown good echocardiographic results.

【 授权许可】

Unknown