Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres

Cancers

卷:13

Sytse F. de Jong¹  Mark J. Arntz²  Jurgen J. Fütterer²  Joey Roosen²  Christiaan G. Overduin²  Marcel J. R. Janssen²  J. Frank W. Nijsen² 

[1] Department of Cardiothoracic Surgery, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands;

[2] Department of Medical Imaging, Radboud Institute for Health Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands;

关键词: SIRT;    radioembolization;    holmium;    MRI;    safety;    compatible;   

DOI  :  10.3390/cancers13215462

来源: DOAJ

【 摘 要 】

Selective internal radiation therapy (SIRT) is a treatment modality for liver tumours during which radioactive microspheres are injected into the hepatic arterial tree. Holmium-166 (¹⁶⁶Ho) microspheres used for SIRT can be visualized and quantified with MRI, potentially allowing for MRI guidance during SIRT. The purpose of this study was to investigate the MRI compatibility of two angiography catheters and a microcatheter typically used for SIRT, and to explore the detectability of ¹⁶⁶Ho microspheres in a flow phantom using near real-time MRI. MR safety tests were performed at a 3 T MRI system according to American Society for Testing of Materials standard test methods. To assess the near real-time detectability of ¹⁶⁶Ho microspheres, a flow phantom was placed in the MRI bore and perfused using a peristaltic pump, simulating the flow in the hepatic artery. Dynamic MR imaging was performed using a 2D FLASH sequence during injection of different concentrations of ¹⁶⁶Ho microspheres. In the safety assessment, no significant heating (ΔT_max 0.7 °C) was found in any catheter, and no magnetic interaction was found in two out of three of the used catheters. Near real-time MRI visualization of ¹⁶⁶Ho microsphere administration was feasible and depended on holmium concentration and vascular flow speed. Finally, we demonstrate preliminary imaging examples on the in vivo catheter visibility and near real-time imaging during ¹⁶⁶Ho microsphere administration in an initial patient case treated with SIRT in a clinical 3 T MRI. These results support additional research to establish the feasibility and safety of this procedure in vivo and enable the further development of a personalized MRI-guided approach to SIRT.

【 授权许可】

Unknown