Case report: Successful induction of buprenorphine/naloxone using a microdosing schedule and assertive outreach

Addiction Science & Clinical Practice

卷:15

S. Elise Durante¹  Mohammadali Nikoo²  Daniel Lin²  Jennifer Rozylo²  Skye P. Barbic²  Steve Mathias²  Pouya Azar²  Keren Mitchell² 

[1] Inner City Youth Program, Providence Health Care;

[2] University of British Columbia;

关键词: Opioid use disorder;    Buprenorphine/naloxone;    Microdosing;    Bernese method;    Induction method;   

DOI  :  10.1186/s13722-020-0177-x

来源: DOAJ

【 摘 要 】

Abstract Background The requirement for moderate withdrawal prior to initiation can be a barrier to buprenorphine/naloxone induction. Case presentation We aimed to use a microdosing regimen to initiate regular dosing of buprenorphine/naloxone in a high-risk patient with a history of failed initiations due, in part, to withdrawal symptoms. Using an assertive outreach model and a buprenorphine/naloxone microdosing schedule, we initiated treatment of an individual’s opioid use disorder. There was a successful buprenorphine/naloxone microdosing induction as the team reached a therapeutic dose of buprenorphine/naloxone. Including the induction period, the medication was used consistently for 4 weeks. Conclusions A microdosing schedule can be used to induce a patient onto buprenorphine/naloxone with no apparent withdrawal; gradually reducing illicit substance use. This case report builds on previous literature, highlighting ways to minimize barriers to induction of buprenorphine/naloxone, using a microdosing schedule and assertive outreach. Given the safety profile of buprenorphine and its potential to be a lifesaving intervention, a larger study of microdosing is indicated.

【 授权许可】

Unknown