Addiction Science & Clinical Practice | 卷:15 |
Case report: Successful induction of buprenorphine/naloxone using a microdosing schedule and assertive outreach | |
S. Elise Durante1  Mohammadali Nikoo2  Daniel Lin2  Jennifer Rozylo2  Skye P. Barbic2  Steve Mathias2  Pouya Azar2  Keren Mitchell2  | |
[1] Inner City Youth Program, Providence Health Care; | |
[2] University of British Columbia; | |
关键词: Opioid use disorder; Buprenorphine/naloxone; Microdosing; Bernese method; Induction method; | |
DOI : 10.1186/s13722-020-0177-x | |
来源: DOAJ |
【 摘 要 】
Abstract Background The requirement for moderate withdrawal prior to initiation can be a barrier to buprenorphine/naloxone induction. Case presentation We aimed to use a microdosing regimen to initiate regular dosing of buprenorphine/naloxone in a high-risk patient with a history of failed initiations due, in part, to withdrawal symptoms. Using an assertive outreach model and a buprenorphine/naloxone microdosing schedule, we initiated treatment of an individual’s opioid use disorder. There was a successful buprenorphine/naloxone microdosing induction as the team reached a therapeutic dose of buprenorphine/naloxone. Including the induction period, the medication was used consistently for 4 weeks. Conclusions A microdosing schedule can be used to induce a patient onto buprenorphine/naloxone with no apparent withdrawal; gradually reducing illicit substance use. This case report builds on previous literature, highlighting ways to minimize barriers to induction of buprenorphine/naloxone, using a microdosing schedule and assertive outreach. Given the safety profile of buprenorphine and its potential to be a lifesaving intervention, a larger study of microdosing is indicated.
【 授权许可】
Unknown