Identification of Ferroptosis-Related Biomarkers for Prognosis and Immunotherapy in Patients With Glioma

Frontiers in Cell and Developmental Biology

卷:10

Donglin Lai¹  Xuefeng Gu¹  Changlian Lu¹  Bing Chen¹  Xiaojia Zuo⁴  Junfeng Shi⁵  Yanjun Zheng⁶  Dingsheng Liu⁶ 

[1] Health Sciences, Shanghai, China;

[2] Department of Neurosurgery, Affiliated Hospital of Guangdong Medical University, Guangzhou, China;

[3] Department of Prosthodontics, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

[4] School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China;

[5] Shanghai Engineering Research Center of Advanced Dental Technology and Materials, National Clinical Research Center for Oral Diseases, Shanghai, China;

[6] Shanghai Key Laboratory of Molecular Imaging, Zhoupu Hospital, Shanghai University of Medicine &

关键词: ferroptosis;    lncRNA;    biomarker;    prognosis;    immune checkpoint;    immunotherapy;   

DOI  :  10.3389/fcell.2022.817643

来源: DOAJ

【 摘 要 】

Ferroptosis is a novel type of iron- and ROS-dependent cell death and is involved in various diseases. LncRNAs are involved and play important roles in the occurrence and development of several cancers. However, researches about the role of ferroptosis-related lncRNAs in glioma are relatively rare. Here, we identified nine ferroptosis-related lncRNAs and then constructed a prognostic model by the LASSO and Cox analysis. The model could predict overall survival with high sensitivity and specificity according to ROC curves. In addition, the cell cycle, p53 signaling, apoptosis, and oxidative phosphorylation pathways were obviously enriched in the pathogenesis of glioma by gene set enrichment analysis. A nomogram was constructed by integrating several independent prognostic clinicopathological features, and it could provide a valuable predictive tool for overall survival. Furthermore, a strong correlation between these nine lncRNAs and immunotherapy was found. Glioma patients in the high-risk group had higher TMB using somatic mutation data, different immune infiltration, and higher expression of immune checkpoints, indicating these patients might benefit from immune checkpoint inhibitor therapy. In summary, these nine ferroptosis-related lncRNAs were promising biomarkers for predicting overall survival and guiding immunotherapy or future immune checkpoint inhibitor development for glioma patients.

【 授权许可】

Unknown