Diet Quality Is Associated with Cardiometabolic Outcomes in Survivors of Childhood Leukemia

Nutrients

卷:12

JamesR. Hebert¹  Nitin Shivappa¹  Valérie Marcil²  Sophia Morel²  Sophie Bérard²  Emile Levy²  Emma Teasdale²  Caroline Laverdière³  Daniel Sinnett³ 

[1] Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA;

[2] Research Centre, Sainte-Justine University Health Center, Department of Nutrition, Université de Montréal, Montreal, QC H3T 1C5, Canada;

[3] Research Centre, Sainte-Justine University Health Center, Department of Pediatrics, Université de Montréal, Montreal, QC H3T 1C5, Canada;

关键词: survivors;    pediatrics;    oncology;    acute lymphoblastic leukemia;    dietary scores;    cardiometabolic complications;   

DOI  :  10.3390/nu12072137

来源: DOAJ

【 摘 要 】

There is little information about how diet influences the health of childhood acute lymphoblastic leukemia (cALL) survivors. This study explores the associations between diet quality indices, cardiometabolic health indicators and inflammatory biomarkers among cALL survivors. Participants were part of the PETALE study (n = 241, median age: 21.7 years). Adherence to 6 dietary scores and caloric intake from ultra-processed foods were calculated. Multivariate logistirac regressions, Student t-tests and Mann-Whitney tests were performed. We found that 88% of adults and 46% of children adhered poorly to the Mediterranean diet, 36.9% had poor adherence to the World Health Organisation (WHO) recommendations and 76.3% had a diet to be improved according to the HEI-2015 score. On average, ultra-processed foods accounted for 51% of total energy intake. Low HDL-C was associated with a more inflammatory diet (E-DIITM score) and higher intake of ultra-processed foods. A greater E-DII score was associated with elevated insulin resistance (HOMA-IR), and consumption of ultra-processed foods was correlated with high triglycerides. Circulating levels of TNF-α, adiponectin and IL-6 were influenced by diet quality indices, while CRP and leptin were not. In conclusion, survivors of cALL have poor adherence to dietary recommendations, adversely affecting their cardiometabolic health.

【 授权许可】

Unknown