The prognostic value of whole blood SOX2, NANOG and OCT4 mRNA expression in advanced small-cell lung cancer

Radiology and Oncology

卷:50

Korošec Peter¹  Koren Ana¹  Sodja Eva¹  Cufer Tanja¹  Rijavec Matija¹  Sadikov Aleksander² 

[1] University Clinic Golnik, Golnik, Slovenia;

[2] University of Ljubljana, Faculty of Computer and Information Science, Ljubljana, Slovenia;

关键词: small-cell lung cancer;    cancer stem cell markers;    sox2;    oct4;    nanog;    mrna expression;    prognosis;   

DOI  :  10.1515/raon-2015-0027

来源: DOAJ

【 摘 要 】

The data on expression and clinical impact of cancer stem cell markers SOX2, NANOG and OCT4 in lung cancer is still lacking. The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung cancer (SCLC) patients and healthy controls, and to correlate mRNA expression with progression-free survival (PFS) after first-line chemotherapy and overall survival (OS) in advanced SCLC patients.

【 授权许可】

Unknown