Increased Left Inferior Temporal Gyrus Was Found in Both Low Function Autism and High Function Autism

Frontiers in Psychiatry

卷:9

Yi Huang¹  Kuifang Guo²  Pingyuan Yang²  Xiao Hu²  Mingjing Situ²  Jia Cai² 

[1] Brain Research Center, West China Hospital of Sichuan University, Chengdu, China;

[2] Mental Health Center, West China Hospital of Sichuan University, Chengdu, China;

[3] Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China;

关键词: low functioning autism;    high functioning autism;    inferior temporal gyrus;    VBM;    structural MRI;   

DOI  :  10.3389/fpsyt.2018.00542

来源: DOAJ

【 摘 要 】

Previous neuroimaging studies of autism spectrum disorder (ASD) have focused on subjects with IQ > 70 or ASD without considering IQ levels. It remains unclear whether differences in brain anatomy in this population are associated with variations in clinical phenotype. In this study, 19 children with low functioning autism (LFA) and 19 children with high functioning autism (HFA) were compared with 27 healthy controls (HC). We found increased gray matter volume (GMV) in the left inferior temporal gyrus in subjects with both HFA and LFA and increased GMV of left middle temporal gyrus BA21 was found only in the LFA group. A significant negative correlation was found between the left inferior temporal gyrus (LITG) and the score of repetitive behavior in the HFA group.

【 授权许可】

Unknown