Rare cases of laboratory tests discrepancies in diagnostics of pediatric Burkitt lymphoma/leukemia

Onkogematologiâ

卷:13

L. A. Shchekina¹  A. M. Popov²  G. A. Tsaur²  M. V. Gorchakova²  Yu. V. Olshanskaya³  E. A. Zerkalenkova³  N. V. Miakova⁴  l. G. Fechina⁴  Yu. G. Abugova⁴  E. V. Samochatova⁴  O. I. Illarionova1⁴  I. A. Demina⁴  M. B. Belogurova⁵  E. E. Zueva⁵  G. I. Uleiskaya⁶  A. N. Kazakova⁷  A. A. Maschan⁸  E. B. Rusanova⁹  T. Yu. Verzhbitskaya⁹ 

[1] Ariel University, Faculty of Natural Sciences, Department of Molecular Biology.;

[2] Research Institute of Medical Cell Technologies.;

[3] City Clinical Hospital No. 31.;

[4] Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of Russia.;

[5] I.P. Pavlov First Saint Petersburg State Medical University.;

[6] I.P. Pavlov First Saint Petersburg State Medical University;

[7] St. Petersburg Clinical Scientific and Practical Center of Specialized Medical Assistance (Oncological).;

[8] Sverdlovsk Regional Clinical Children’s Hospital No 1.;

[9] Sverdlovsk Regional Clinical Children’s Hospital No 1;

关键词: сonclusion. the cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of bl.;   

DOI  :  10.17650/1818-8346-2018-13-3-76-82

来源: DOAJ

【 摘 要 】

Introduction. The main features of bone marrow blasts cells in Burkitt lymphoma/leukemia (BL) are L3 morphology, mature immunophenotype of blasts with surface IgM expression, and presence of typical MYC gene rearrangements.The aim of the study was to show discrepancy examples in laboratory signs of BL.Patients and methods. 10 patients (8 boys and 2 girls) aged 1 to 18 years were included in the present study. The inclusion criterion was the identification of discrepancies between flow cytometric, morphological and cytogenetic data.Results. In 2 cases there were no rearrangements of the MYC gene. In 2 patients, the L2 morphological variant went against the presence of typical MYC gene rearrangements. In one case, undifferentiated blasts cells were described by morphology together with presence of surface IgM, and atypical genetics. In 8 patients, there was no expression of surface IgM. Of these, patients with absence of cytomorphological data cytometric and genetic data were controversial.Сonclusion. The cases presented in this study and the cases described in the literature demonstrate the importance of an attentive and comprehensive approach in evaluating the results of laboratory tests in the diagnosis of BL.

【 授权许可】

Unknown