Immunobiological Characteristics of Cholera Toxin B-Subunit

Проблемы особо опасных инфекций

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T. L. Zakharova¹  A. L. Kravtsov¹  N. I. Smirnova¹  T. N. Shchukovskaya¹  S. A. Bugorkova¹  N. I. Belyakova¹  S. A. Eremin¹  S. N. Klyueva¹  T. P. Shmel’Kova¹  A. K. Nikiforov¹  O. A. Volokh¹ 

[1] Russian Research Anti-Plague Institute “Microbe”;

关键词: в-субъединица холерного токсина;    токсичность;    протективность;    апоптоз;    антитоксические антитела;    cholera toxin b-subunit;    toxicity;    protective ability;    apoptosis;    anti-toxic antibodies;   

DOI  :  10.21055/0370-1069-2012-3-67-70

来源: DOAJ

【 摘 要 】

Carried out was immunobiological evaluation of cholera toxin B subunit preparations obtained using different experimental and production methods. It was demonstrated that B subunit preparations were non-toxic for biomodels and did not cause significant pathological alterations in their organs and tissues. They also did not alter the condition of immunocompetent cells at different stages of their cycle, and promote anti-toxic antibodies production. Thus, B subunit preparations under study can be considered as promising components of cholera vaccine.

【 授权许可】

Unknown