The Role of Oxidative Stress and Hormones in Controlling Obesity

Frontiers in Endocrinology

卷:10

Marina Di Domenico¹  Mariarosaria Boccellino²  Federica Pinto²  Giuliana Settembre²  Mario Coppola²  Lucio Quagliuolo²  Antonella Sciarra³  Kenan Ferati⁴  Arbëresha Bexheti-Ferati⁴  Antonio Romano⁵  Maria Contaldo⁵  Giuseppe Andrea Ferraro⁶  Giovanni Francesco Nicoletti⁶ 

[1] Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, United States;

[2] Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy;

[3] Department of Translational Medicad Sciences, University of Campania Luigi Vanvitelli, Naples, Italy;

[4] Faculty of Medicine, University of Tetovo, Tetovo, Macedonia;

[5] Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy;

[6] Plastic Surgery Unit, Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy;

关键词: obesity;    oxidative stress;    thyroid;    gut hormones;    microbiota;    wound healing;   

DOI  :  10.3389/fendo.2019.00540

来源: DOAJ

【 摘 要 】

The accumulation of adipose tissue in the body occurs because the energy introduced with food and drink exceeds that expense, but to understand why this imbalance is established and why it is maintained over time, it is important to consider the main causes and risk factors of excess weight. In this review, we will refer to the main factors linked to obesity, starting from oxidative stress to hormonal factors including the role of obesity in breast cancer. Among the many hypotheses formulated on the etiopathology of obesity, a key role can be attributed to the relationship between stress oxidative and intestinal microbiota. Multiple evidences tend to show that genetic, epigenetic, and lifestyle factors contribute to determine in the obese an imbalance of the redox balance correlated with the alteration of the intestinal microbial flora. Obesity acts negatively on the wound healing, in fact several studies indicate morbid obesity significantly increased the risk of a post-operative wound complication and infection. Currently, in the treatment of obesity, medical interventions are aimed not only at modifying caloric intake, but also to modulate and improve the composition of diet with the aim of rebalancing the microbiota-redox state axis.

【 授权许可】

Unknown