Biocompatibility and Biological Performance Evaluation of Additive-Manufactured Bioabsorbable Iron-Based Porous Suture Anchor in a Rabbit Model

International Journal of Molecular Sciences

卷:22

Hsin-Hsin Shen¹  Chih-Chieh Huang¹  Shin-I Huang¹  Pei-I Tsai¹  Kuo-Yi Yang¹  Chun-Kuan Lu²  Hon-Lok Lo³  Wen-Chih Liu³  Jui-Sheng Sun⁴  Chih-Yu Chen⁵  Yu-Min Huang⁵  Chen-Kun Liaw⁵  Chien-Cheng Tai⁶  Yen-Hua Huang⁶  Tzu-Hung Lin⁷ 

[1] Biomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Chutung, Hsinchu 310401, Taiwan;

[2] Department of Orthopaedics, Park One International Hospital, Kaohsiung 813322, Taiwan;

[3] Department of Orthopedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan;

[4] Department of Orthopedics, China Medical University, Taichung 40202, Taiwan;

[5] Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan;

[6] Internal Ph.D. Program for Cell Therapy and Regeneration Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan;

[7] Material and Chemical Research Laboratories, Industrial Technology Research Institute, Hsinchu 31040, Taiwan;

关键词: additive manufacturing (3D printing);    bioabsorbable;    iron-based;    suture anchor;   

DOI  :  10.3390/ijms22147368

来源: DOAJ

【 摘 要 】

This study evaluated the biocompatibility and biological performance of novel additive-manufactured bioabsorbable iron-based porous suture anchors (iron_SAs). Two types of bioabsorbable iron_SAs, with double- and triple-helical structures (iron_SA_2_helix and iron_SA_3_helix, respectively), were compared with the synthetic polymer-based bioabsorbable suture anchor (polymer_SAs). An in vitro mechanical test, MTT assay, and scanning electron microscope (SEM) analysis were performed. An in vivo animal study was also performed. The three types of suture anchors were randomly implanted in the outer cortex of the lateral femoral condyle. The ultimate in vitro pullout strength of the iron_SA_3_helix group was significantly higher than the iron_SA_2_helix and polymer_SA groups. The MTT assay findings demonstrated no significant cytotoxicity, and the SEM analysis showed cells attachment on implant surface. The ultimate failure load of the iron_SA_3_helix group was significantly higher than that of the polymer_SA group. The micro-CT analysis indicated the iron_SA_3_helix group showed a higher bone volume fraction (BV/TV) after surgery. Moreover, both iron SAs underwent degradation with time. Iron_SAs with triple-helical threads and a porous structure demonstrated better mechanical strength and high biocompatibility after short-term implantation. The combined advantages of the mechanical superiority of the iron metal and the possibility of absorption after implantation make the iron_SA a suitable candidate for further development.

【 授权许可】

Unknown