Recent Progress in Cell Therapy in Solid Organ Transplantation

International Journal of Organ Transplantation Medicine

卷:8

RF Saidi¹  R Garakani² 

[1] Department of Surgery, Digestive Disease Research Institute, Shariati Hospital, Tehran, Iran;

[2] Division of Organ Transplantation, Department of Surgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence RI, USA;

关键词: Stem cells;    Organ transplantation;    T-Lymphocytes, Regulatory;    Immunosuppression;    Immune tolerance;   

DOI  :  

来源: DOAJ

【 摘 要 】

There has been ample of preclinical and animal studies showing efficacy and safety of using various cells, such as stem cells or T regulatory cells, after transplantation for tissue repair, immunosuppression or tolerance induction. However, there has been a significant progress recently using cell therapy in solid organ transplantation in small clinical trials. Recent results have been promising and using cell therapy in solid organ transplantation seems feasible and safe. However, there are more hurdles to overcome such as dose and timing of the infusions. Current studies mainly focused on live donor kidney transplantation. Expansion of current regimes to other organs and deceased donor transplantation would be crucial.

【 授权许可】

Unknown