Extending the utility of [Pd(NHC)(cinnamyl)Cl] precatalysts: Direct arylation of heterocycles

Beilstein Journal of Organic Chemistry

卷:8

Anthony Chartoire¹  Anthony R. Martin¹  Alexandra M. Z. Slawin¹  Steven P. Nolan¹ 

[1] EaStCHEM School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, UK;

关键词: C–H functionalization;    direct arylation;    heterocycles;    N-heterocyclic carbenes;    palladium;   

DOI  :  10.3762/bjoc.8.187

来源: DOAJ

【 摘 要 】

The use of [Pd(NHC)(cinnamyl)Cl] precatalysts in the direct arylation of heterocycles has been investigated. Among four different precatalysts, [Pd(SIPr)(cinnamyl)Cl] proved to be the most efficient promoter of the reaction. The C–H functionalization of sulfur- or nitrogen-containing heterocycles has been achieved at low catalyst loadings. These catalyst charges range from 0.1 to 0.01 mol % palladium.

【 授权许可】

Unknown