FOXP3+T-REGULATORY LYMPHOCYTESAND AUTOANTIBODIES IN PATIENTSWITH ARTERIAL HYPERTENSION,ASSOCIATED WITH DIABETESMELLITUS TYPE 2 AND IMPAIREDGLUCOSE TOLERANCE

Medicinskaâ Immunologiâ

卷:15

N. M. Zheltonogova¹  I. V. Kologrivova¹  O. A. Koshelskaya¹  I. V. Vinnizkaya¹  A. M. Gusakova¹  T. E. Suslova¹  O. A. Trubacheva¹ 

[1] Research Institute of Cardiology, Russian Academy of Medical Sciences, Siberian Branch, Tomsk;

关键词: autoantibodies;    foxp3+t-regulatory lymphocytes;    diabetes mellitus type 2;    impaired glucose tolerance;   

DOI  :  10.15789/1563-0625-2013-2-155-162

来源: DOAJ

【 摘 要 】

When studying patients with an association of arterial hypertension and type 2 diabetes mellitus, we have shown a lower number of FoxP3+T-regulatory cells, as well as elevated levels of anti-myocardial antibodies and autoantibodies to nuclear antigens. In a group with combination of impaired glucose tolerance and arterial hypertension, a decrease in T-regulatory lymphocytes’ numbers, along with increased rheumatoid factor and antimitochondrial autoantibodies concentrations were observed. Arterial hypertension was combined with dyslipidemia, being accompanied by higher levels of rheumatoid factor and antibodies to nuclear antigens. In all these clinical groups, we revealed close correlations between concentrations of autoantibodies, FoxP3+T-regulatory lymphocyte scores, and parameters of carbohydrate and lipid metabolism. The results, obtained in present study, allow us to suggest that metabolic disturbances may be associated with altered immune tolerance mechanisms and activation of humoral immune response that are detectable since early stages of the disease and may contribute to development of complications occurring in diabetes mellitus type 2.

【 授权许可】

Unknown