Brain gene expression in a novel mouse model of postpartum mood disorder

Translational Neuroscience

卷:10

Davies William¹  Humby Trevor¹ 

[1] School of Psychology, Cardiff University, Cardiff CF10 3AT, Cardiff, UK;

关键词: female;    g-protein coupled receptor;    mice;    postpartum depression;    postpartum psychosis;    steroid sulfatase;   

DOI  :  10.1515/tnsci-2019-0030

来源: DOAJ

【 摘 要 】

Steroid sulfatase (STS) cleaves sulfate groups from steroid hormones; its expression/activity increases in late pregnancy and into the postpartum period. STS-deficient human and mouse mothers display elevated psychopathology and abnormal behaviour respectively; in mice, these effects can be partially normalised by antipsychotic (ziprasidone) administration.

【 授权许可】

Unknown