Serine/Threonine Protein Kinase STK16

International Journal of Molecular Sciences

卷:20

Xin Zhang¹  Junjun Wang¹  Xinmiao Ji¹  Juanjuan Liu² 

[1] High Magnetic Field Laboratory, Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China;

[2] School of Life Sciences, Anhui University, Hefei 230601, China;

关键词: STK16;    kinase;    fatty acylation;    phosphorylation;    Golgi apparatus;    protein secretion and sorting;    cell cycle;   

DOI  :  10.3390/ijms20071760

来源: DOAJ

【 摘 要 】

STK16 (Ser/Thr kinase 16, also known as Krct/PKL12/MPSK1/TSF-1) is a myristoylated and palmitoylated Ser/Thr protein kinase that is ubiquitously expressed and conserved among all eukaryotes. STK16 is distantly related to the other kinases and belongs to the NAK kinase family that has an atypical activation loop architecture. As a membrane-associated protein that is primarily localized to the Golgi, STK16 has been shown to participate in the TGF-β signaling pathway, TGN protein secretion and sorting, as well as cell cycle and Golgi assembly regulation. This review aims to provide a comprehensive summary of the progress made in recent research about STK16, ranging from its distribution, molecular characterization, post-translational modification (fatty acylation and phosphorylation), interactors (GlcNAcK/DRG1/MAL2/Actin/WDR1), and related functions. As a relatively underexplored kinase, more studies are encouraged to unravel its regulation mechanisms and cellular functions.

【 授权许可】

Unknown