Autophagic Organelles in DNA Damage Response

Frontiers in Cell and Developmental Biology

卷:9

BuHyun Youn¹  Jeongha Kim²  Hyunwoo Kim²  Haksoo Lee²  Sungmin Lee²  HyeSook Youn³  Ki Moon Seong⁴ 

[1] Department of Biological Sciences, Pusan National University, Busan, South Korea;

[2] Department of Integrated Biological Science, Pusan National University, Busan, South Korea;

[3] Department of Integrative Bioscience and Biotechnology, Sejong University, Seoul, South Korea;

[4] Laboratory of Low Dose Risk Assessment, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea;

关键词: DNA damage response;    mitophagy;    ER-phagy;    ribophagy;    therapeutic approach;   

DOI  :  10.3389/fcell.2021.668735

来源: DOAJ

【 摘 要 】

Autophagy is an important subcellular event engaged in the maintenance of cellular homeostasis via the degradation of cargo proteins and malfunctioning organelles. In response to cellular stresses, like nutrient deprivation, infection, and DNA damaging agents, autophagy is activated to reduce the damage and restore cellular homeostasis. One of the responses to cellular stresses is the DNA damage response (DDR), the intracellular pathway that senses and repairs damaged DNA. Proper regulation of these pathways is crucial for preventing diseases. The involvement of autophagy in the repair and elimination of DNA aberrations is essential for cell survival and recovery to normal conditions, highlighting the importance of autophagy in the resolution of cell fate. In this review, we summarized the latest information about autophagic recycling of mitochondria, endoplasmic reticulum (ER), and ribosomes (called mitophagy, ER-phagy, and ribophagy, respectively) in response to DNA damage. In addition, we have described the key events necessary for a comprehensive understanding of autophagy signaling networks. Finally, we have highlighted the importance of the autophagy activated by DDR and appropriate regulation of autophagic organelles, suggesting insights for future studies. Especially, DDR from DNA damaging agents including ionizing radiation (IR) or anti-cancer drugs, induces damage to subcellular organelles and autophagy is the key mechanism for removing impaired organelles.

【 授权许可】

Unknown