Association Between Stroke Risk and Metformin Use in Hemodialysis Patients With Diabetes Mellitus: A Nested Case–Control Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

卷:6

Yen‐Chung Lin¹  His‐Hsien Chen¹  Te‐Chao Fang¹  Yueh‐Lin Wu¹  Chih‐Chin Kao¹  Jin‐Shuen Chen²  Chu‐Lin Chou²  Li‐Ying Chen³  Li‐Nien Chien⁴ 

[1] Division of Nephrology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan;

[2] Division of Nephrology, Department of Internal Medicine, Tri‐Service General Hospital, National Defense Medical Center, Taipei, Taiwan;

[3] Health and Clinical Data Research Center, College of Public Health, Taipei Medical University, Taipei, Taiwan;

[4] School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan;

关键词: diabetes mellitus (kidney);    diabetes mellitus;    diabetic therapy/glitazones;    hemodialysis;    metformin;    stroke;   

DOI  :  10.1161/JAHA.117.007611

来源: DOAJ

【 摘 要 】

BackgroundMetformin use reduces the incidence and severity of stroke in patients with type 2 diabetes mellitus (DM). The benefits of metformin for stroke have not been examined in hemodialysis patients with DM. Methods and ResultsUsing the National Health Insurance Research Database, we identified 17 760 patients with DM and new‐onset hemodialysis between 2001 and 2013. Of these, 1898 patients hospitalized for either ischemic or hemorrhagic stroke were matched to 7592 control patients according to sex, age, and year of initial hemodialysis therapy by using incidence sampling. The association between metformin use and stroke risk was estimated using conditional logistic regression after adjustment for hemodialysis frequency, comorbidity, and prescribed medications. Metformin use was recorded before the date of stroke admission and the date of pseudostroke of the case and control patients, respectively. Results showed that hemodialysis patients with ischemic stroke were more likely to use metformin than the controls 1 year before the date of stroke admission (adjusted odds ratio: 1.64; 95% confidence interval, 1.32–2.04). The association was evident within 90 days before the index date (adjusted odds ratio: 1.81; 95% confidence interval, 1.27–2.60). The results were consistent with those of hemodialysis patients with hemorrhagic stroke. Metformin use remained a risk factor for stroke in patients treated with antihypertensive, sulfonylurea, and antiplatelet drugs. ConclusionsThis nested case–control study is the first to show that metformin use is associated with stroke risk in hemodialysis patients with DM. We suggest that metformin should not be used by hemodialysis patients with DM.

【 授权许可】

Unknown