Renal cell carcinoma with unusual metachronous metastasis up to 22 years after nephrectomy: two case reports

Journal of Medical Case Reports

卷:15

F. Bruckschen¹  A. Sagir¹  C. D. Gerharz² 

[1] Department of Gastroenterology, Academic Teaching Hospital Bethesda Duisburg;

[2] Department of Pathology, Academic teaching Hospital Bethesda Duisburg;

关键词: Renal cell carcinoma;    Metastasis;    Pancreas;    Omentum;    Liver;   

DOI  :  10.1186/s13256-021-03098-5

来源: DOAJ

【 摘 要 】

Abstract Introduction Renal cell carcinoma is the third most common malignant tumor in the urogenital tract. An estimated 25% of renal cell carcinomas are in stage IV when diagnosed. The 5-year-survival with stage IV is about 20%. Late metastases are found after an extended disease-free interval up to 20 years after primary nephrectomy. Case presentation Here, we present two cases with late-onset metastasis of renal cell carcinoma with different clinical presentations. The first patient, an 88-year-old Caucasian man, presented with bleeding of the upper gastrointestinal tract. Biopsies taken from the duodenal bulb showed a tumor compatible with a solitary metastasis from renal cell carcinoma 22 years ago. The second patient, a 79-year-old Caucasian man, consulted our gastroenterological department with results of an outpatient computed tomography scan with multiple suspected tumor areas in the liver, omentum, thyroid, and mediastinum. A computed tomography-guided liver biopsy was performed that showed a clear-cell tumor consistent with a metastasis of the renal cell carcinoma 17 years ago. Conclusion Both cases show that patients with a history of renal cell carcinoma should be followed up for a longer time than patients with other malignant tumors.

【 授权许可】

Unknown