Akermanite used as an alkaline biodegradable implants for the treatment of osteoporotic bone defect

Bioactive Materials

卷:1

William W. Lu¹  Haobo Pan²  Xiaoli Zhao²  Ting Wang²  Wenlong Liu²  Xiuli Dan³ 

[1] Department of Orthopaedics and Traumatology, Faculty of Medicine, The University of Hong Kong, Hong Kong;

[2] Research Center for Human Tissue and Organs Degeneration, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China;

[3] School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong;

关键词: Osteoporotic bone defect;    Akermanite;    Material-bone interface;    Microenvironment pH;   

DOI  :  10.1016/j.bioactmat.2016.11.004

来源: DOAJ

【 摘 要 】

In osteoporosis scenario, tissue response to implants is greatly impaired by the deteriorated bone regeneration microenvironment. In the present study, a Mg-containing akermanite (Ak) ceramic was employed for the treatment of osteoporotic bone defect, based on the hypothesis that both beneficial ions (e.g. Mg2+ ect.) released by the implants and the weak alkaline microenvironment pH (μe-pH) it created may play distinct roles in recovering the abnormal bone regeneration by stimulating osteoblastic anabolic effects. The performance of Ak, β-tricalcium phosphate (β-TCP) and Hardystone (Har) in healing a 3 mm bone defect on the ovariectomized (OVX) osteoporotic rat model was evaluated. Our results indicated that, there's more new bone formed in Ak group than in β-TCP or Har group at week 9. The initial μe-pHs of Ak were significantly higher than that of the β-TCP and Blank group, and this weak alkaline condition was maintained till at least 9 weeks post-surgery. Increased osteoblastic activity which was indicated by higher osteoid secretion was observed in Ak group at week 4 to week 9. An intermediate layer which was rich in phosphorus minerals and bound directly to the new forming bone was developed on the surface of Ak. In a summary, our study demonstrates that Ak exhibits a superior bone regenerative performance under osteoporosis condition, and might be a promising candidate for the treatment of osteoporotic bone defect and fracture.

【 授权许可】

Unknown