Results of a national school-based deworming programme on soil-transmitted helminths infections and schistosomiasis in Kenya: 2012–2017

Parasites & Vectors

卷:12

Matthew C. Freeman¹  Jimmy Kihara²  Charles Mwandawiro²  Collins Okoyo²  Elses Simiyu²  Sammy M. Njenga²  Suzy J. Campbell³  Stella Kepha⁴  Simon J. Brooker⁴ 

[1] Department of Environmental Health, Rollins School of Public Health, Emory University;

[2] Eastern and Southern Africa Centre of International Parasite Control, Kenya Medical Research Institute (KEMRI);

[3] Evidence Action;

[4] Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medical Medicine;

关键词: School-based deworming;    Soil-transmitted helminths;    Schistosomiasis;   

DOI  :  10.1186/s13071-019-3322-1

来源: DOAJ

【 摘 要 】

Abstract Background Soil-transmitted helminth (STH) and schistosome infections are among the most prevalent neglected tropical diseases (NTDs) in the world. School-aged children are particularly vulnerable to these chronic infections that can impair growth, nutritional status and cognitive ability. Mass drug administration (MDA) delivered either once or twice annually is a safe and effective approach recommended by the World Health Organization (WHO) to reduce worm burden. In 2012, Kenya began a national school-based deworming programme (NSBDP) aimed at reducing infection and associated morbidity. The change in prevalence and intensity of these infections was monitored over five years (2012–2017). Here, we present the changes in STH and schistosome infections between baseline and endline assessments, as well as explore the yearly patterns of infection reductions. Methods We used series of pre- and post-MDA intervention, repeat cross-sectional surveys in a representative, stratified, two-stage sample of schools in 16 counties of Kenya. The programme consisted of two tiers of monitoring; a national baseline, midterm and endline surveys consisting of 200 schools, and pre- and post-MDA surveys conducted yearly consisting of 60 schools. Stool and urine samples were collected from randomly selected school children and examined for STH and schistosome infections using Kato-Katz and urine filtration techniques respectively. Results Overall, 32.3%, 16.4% and 13.5% of the children were infected with any STH species during baseline, midterm and endline assessment, respectively, with a relative reduction of 58.2% over the five-year period. The overall prevalence of S. mansoni was 2.1%, 1.5% and 1.7% and of S. haematobium was 14.8%, 6.8% and 2.4%, respectively, for baseline, midterm and endline surveys. We observed inter-region and inter-county heterogeneity variation in the infection levels. Conclusions The analysis provided robust assessment of the programme and outlined the current prevalence, mean intensity and re-infection pattern of these infections. Our findings will allow the Government of Kenya to make informed decisions on the strategy to control and eliminate these NTDs. Our results suggest that complimentary interventions may have to be introduced to sustain the chemotherapeutic gains of MDA and accelerate attainment of elimination of these NTDs as a public health problem in Kenya.

【 授权许可】

Unknown