Behavioral and Psychological Effects of Coronavirus Disease-19 Quarantine in Patients With Dementia

Frontiers in Psychiatry

卷:11

Ildebrando Appollonio¹  Valeria Isella¹  Carlo Ferrarese¹  Nicola Vanacore²  Massimo Filippi⁴  Federica Agosta⁴  Paolo Caffarra⁵  Renato Sambati⁷  Giancarlo Logroscino⁷  Gioacchino Tedeschi⁸  Elena Carapelle⁹  Giulia Sandri⁹  Ilaria Pedriali⁹  Alberto Trequattrini⁹  Rosanna Colao⁹  Miriam Accogli⁹  Chiara Criscuolo⁹  Annalisa Vezzosi⁹  Daniela Gragnaniello⁹  Anna Paola Mazzarolo⁹  Giulia Camporese⁹  Alfonsina Casalena⁹  Luisa Sambati⁹  Laura Detogni⁹  Pasqualina Insarda⁹  Marco Guidi⁹  Francesca Frangipane⁹  Veronica Redaelli⁹  Valeria Blandino⁹  Andrea Marcinnò⁹  Giovanna Nicoletta Trevisi⁹  Maria Giuseppina Mascia⁹  Marcella Caggiula⁹  Fulvio Da Re⁹  Gabriella Cacchiò⁹  Cristina Bergamelli⁹  Simona Sacco⁹  Giulia Caruso⁹  Matteo De Bartolo⁹  Marino Formilan⁹  Chiara Galli⁹  Maria Carmela Lechiara⁹  Enrico Mossello⁹  Marta Perini⁹  Salvatore Pezzuto⁹  Fausto Roveta⁹  Stefano Mozzetta⁹  Paola De Martino⁹  Katia Fabi⁹  Giulia Fichera⁹  Giuseppe Caravaglios⁹  Mirella Russo⁹  Cristina Paci⁹  Antonio Milia⁹  Luca Cuffaro⁹  Alessandro Iavarone⁹  Antonella Battaglia⁹  Giuseppe Bruno⁹  Gianfranco Spalletta⁹  Giuseppe Di Fede⁹  Daniela Coppa⁹  Anna Rosa Casini⁹  Renzo Rozzini⁹  Matteo Cotta Ramusino⁹  Rossano Angeloni⁹  Lenino Peluso⁹  Giuseppina Pilia⁹  Paola Caroppo⁹  Rossella Santoro⁹  Desirée Estela Porcari⁹  Annaelisa Castellano⁹  Claudia Carrarini⁹  Gloria Tognoni⁹  Petra Bevilacqua⁹  Federica Lino⁹  Edoardo G. Spinelli⁹  Alberto Grassini⁹  SINdem COVID-19 Study Group⁹  Andrea Fabbo⁹  Nerisa Banaj⁹  Cinzia Bussè⁹  Cinzia Giuli⁹  Anna Vittoria Marta Orsini⁹  Michela Brambilla⁹  Erica Gallo⁹  Francesca Ursini⁹  Rossella Petrucci⁹  Valentina Bessi⁹  Maria Mirabelli⁹  Brigida Coluccia⁹  Annalisa Chiari⁹  Samantha Pradelli⁹  Tommaso Piccoli⁹  Gianfranco Puccio⁹  Simona Luzzi⁹  Serena Amici⁹  Luca Antonina⁹  Livia Ludovico⁹  Antonella Vasquez Giuliano⁹  Pietro Tiraboschi⁹  Roberto Monastero⁹  Federica Lupo⁹  Gianluigi Calabrese⁹  Elena Salvatore⁹  Valeria Calsolaro⁹  Giuseppe Magnani⁹  Giulia Perini⁹  Maurizio Gallucci⁹  Patrizia Mecocci⁹  Noemi Martellacci⁹  Alessandra Coin⁹  Silvia Magarelli⁹  Eduardo Cumbo⁹  Virginia Cipollini⁹  Francesca Caso⁹  Francesca Sala⁹  Patrizia Sucapane⁹  Valeria Putzu⁹  Sabrina Esposito⁹  Innocenzo Rainero¹⁰  Alessandro Vacca¹⁰  Chiara Cupidi¹¹  Paolo Provero¹²  Ilaria Pettenuzzo¹⁴  Annachiara Cagnin¹⁴  Elisa Rubino¹⁵  Laura Bonanni¹⁶  Valeria Guglielmi¹⁷  Camillo Marra¹⁷  Davide Quaranta¹⁷  Amalia C. Bruni¹⁸  Raffaele Di Lorenzo¹⁸  Valentina Laganà¹⁸ 

[1] 0Department of Medicine and Surgery and Milan Center for Neuroscience (NeuroMi), University of Milano – Bicocca, Monza, Italy;

[2] 1National Institute of Health, Rome, Italy;

[3] 2Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy;

[4] 3Vita-Salute San Raffaele University, Milan, Italy;

[5] 4Unit of Neuroscience, University of Parma, Parma, Italy;

[6] 5Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari, Bari, Italy;

[7] 6Department of Basic Medicine Neuroscience and Sense Organs, University Aldo Moro Bari, Bari, Italy;

[8] 7Department of Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy;

[9] ;

[10] Aging Brain and Memory Clinic, Department of Neuroscience, University of Torino, Turin, Italy;

[11] CDCD Ospedale del Delta, AUSL Ferrara, Ferrara, Italy;

[12] Center for Omics Sciences, IRCCS San Raffaele Scientific Institute, Milan, Italy;

[13] Department of Molecular Biotechnology and Health Sciences, University of Torino, Turin, Italy;

[14] Department of Neuroscience (DNS), University of Padua, Padua, Italy;

[15] Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Turin, Italy;

[16] Department of Neuroscience, Imaging and Clinical Sciences, University G. d’Annunzio of Chieti-Pescara, Chieti, Italy;

[17] Memory Clinic, Fondazione Policlinico Gemelli, IRCCS Università, Cattolica del Sacro Cuore, Rome, Italy;

[18] Regional Neurogenetic Centre, Department of Primary Care, ASP-CZ, Catanzaro, Italy;

关键词: behavioral and psychological symptoms;    behavioral symptoms;    psychological symptoms;    quarantine;    dementia;    caregiver;   

DOI  :  10.3389/fpsyt.2020.578015

来源: DOAJ

【 摘 要 】

BackgroundIn March 2020, the World Health Organization declared a global pandemic due to the novel coronavirus SARS-CoV-2 and several governments planned a national quarantine in order to control the virus spread. Acute psychological effects of quarantine in frail elderly subjects with special needs, such as patients with dementia, have been poorly investigated. The aim of this study was to assess modifications of neuropsychiatric symptoms during quarantine in patients with dementia and their caregivers.MethodsThis is a sub-study of a multicenter nation-wide survey. A structured telephone interview was delivered to family caregivers of patients with diagnosis of Alzheimer disease (AD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), and vascular dementia (VD), followed regularly at 87 Italian memory clinics. Variations in behavioral and psychological symptoms (BPSD) were collected after 1 month since quarantine declaration and associations with disease type, severity, gender, and caregiver’s stress burden were analyzed.ResultsA total of 4,913 caregivers participated in the survey. Increased BPSD was reported in 59.6% of patients as worsening of preexisting symptoms (51.9%) or as new onset (26%), and requested drug modifications in 27.6% of these cases. Irritability, apathy, agitation, and anxiety were the most frequently reported worsening symptoms and sleep disorder and irritability the most frequent new symptoms. Profile of BPSD varied according to dementia type, disease severity, and patients’ gender. Anxiety and depression were associated with a diagnosis of AD (OR 1.35, CI: 1.12–1.62), mild to moderate disease severity and female gender. DLB was significantly associated with a higher risk of worsening hallucinations (OR 5.29, CI 3.66–7.64) and sleep disorder (OR 1.69, CI 1.25–2.29), FTD with wandering (OR 1.62, CI 1.12–2.35), and change of appetite (OR 1.52, CI 1.03–2.25). Stress-related symptoms were experienced by two-thirds of caregivers and were associated with increased patients’ neuropsychiatric burden (p<0.0001).ConclusionQuarantine induces a rapid increase of BPSD in approximately 60% of patients and stress-related symptoms in two-thirds of caregivers. Health services need to plan a post-pandemic strategy in order to address these emerging needs.

【 授权许可】

Unknown