Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes

Nutrients

卷:12

Antonin Lamaziere¹  Emilie Gauliard¹  Dominique Rainteau¹  Lydie Humbert¹  Nadine Bouby²  Philippe Lesnik³  Pukar KC³  Maryse Guerin³  Joe-Elie Salem³  Maharajah Ponnaiah⁴  Farid Ichou⁴  Jean-Maurice Mallet⁵ 

[1] Centre de Recherche Saint-Antoine, CRSA, AP-HP, Hôpital Saint Antoine, Biochemistry Department, Sorbonne Université, Inserm, F-75012 Paris, France;

[2] Centre de Recherches des Cordeliers (CRC), INSERM, UMRS 1138, F-75006 Paris, France;

[3] Institut National de la Santé et de la Recherche Médicale (INSERM, UMR_S 1166-ICAN), Research Institute of Cardiovascular Disease, Metabolism and Nutrition, Faculté de Médecine—Hôpital Pitié-Salpêtrière, Sorbonne Université, F-75013 Paris, France;

[4] Institute of Cardiometabolism and Nutrition (ICAN), 75013 Paris, France;

[5] Laboratoire des Biomolécules, LBM, Département de Chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France;

关键词: bile acids;    postprandial;    microbiota;    lipoproteins;    LDL;    HDL;   

DOI  :  10.3390/nu12113545

来源: DOAJ

【 摘 要 】

Bile acids (BAs) regulate dietary lipid hydrolysis and absorption in the proximal intestine. Several studies have highlighted a determinant role of circulating levels and/or metabolism of BAs in the pathogenesis of major cardiometabolic diseases. Whether changes in BA profiles are causative or are consequence of these diseases remains to be determined. Healthy male volunteers (n = 71) underwent a postprandial exploration following consumption of a hypercaloric high fat typical Western meal providing 1200 kcal. We investigated variations of circulating levels of 28 BA species, together with BA synthesis marker 7α-hydroxy-4-cholesten-3-one (C4) over an approximately diurnal 12 h period. Analysis of BA variations during the postprandial time course revealed two major phenotypes with opposite fluctuations, i.e., circulating levels of each individual species of unconjugated BAs were reduced after meal consumption whereas those of tauro- and glyco-conjugated BAs were increased. By an unbiased classification strategy based on absolute postprandial changes in BA species levels, we classified subjects into three distinct clusters; the two extreme clusters being characterized by the smallest absolute changes in either unconjugated-BAs or conjugated-BAs. Finally, we demonstrated that our clustering based on postprandial changes in BA profiles was associated with specific clinical and biochemical features, including postprandial triglyceride levels, BMI or waist circumference. Altogether, our study reveals that postprandial profiles/patterns of BAs in response to a hypercaloric high fat challenge is associated with healthy or unhealthy metabolic phenotypes that may help in the early identification of subjects at risk of developing metabolic disorders.

【 授权许可】

Unknown