On the roles of intrinsically disordered proteins and regions in cell communication and signaling

Cell Communication and Signaling

卷:19

A. Keith Dunker¹  Vladimir N. Uversky²  Sarah E. Bondos³ 

[1] Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine;

[2] Department of Molecular Medicine and USF Health Byrd Alzheimer’s Research Institute, Morsani College of Medicine, University of South Florida;

[3] Department of Molecular and Cellular Medicine, Texas A&M Health Science Center;

关键词: Amino acid sequence;    Protein structure;    Disorder prediction;    Intrinsically disordered proteins;   

DOI  :  10.1186/s12964-021-00774-3

来源: DOAJ

【 摘 要 】

Abstract For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured proteins, intrinsically disordered proteins and regions (IDPs and IDRs) also carry out crucial biological functions. For these proteins, the sequence → IDP/IDR ensemble → function paradigm applies primarily to signaling and regulatory proteins and regions. Often, in order to carry out function, IDPs or IDRs cooperatively interact, either intra- or inter-molecularly, with structured proteins or other IDPs or intermolecularly with nucleic acids. In this IDP/IDR thematic collection published in Cell Communication and Signaling, thirteen articles are presented that describe IDP/IDR signaling molecules from a variety of organisms from humans to fruit flies and tardigrades (“water bears”) and that describe how these proteins and regions contribute to the function and regulation of cell signaling. Collectively, these papers exhibit the diverse roles of disorder in responding to a wide range of signals as to orchestrate an array of organismal processes. They also show that disorder contributes to signaling in a broad spectrum of species, ranging from micro-organisms to plants and animals.

【 授权许可】

Unknown