Effectiveness of Brown Algae Extract to Reduce Serum Malondialdehyde and Protein Carbonyl Levels in Streptozotocin-Induced Sprague Dawley Rats

Sains Medika

卷:7

Lusiana Batubara¹  Tri N. Kristina²  Banundari Rachmawati³ 

[1] *Corresponding author:Address: Faculty of Medicine Diponegoro University, Jl. Prof. H. Soedarto, SH Tembalang Semarang, Phone: [phone], Email : [e-mail];

[2] Department of Clinical Pathology, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaFaculty of Medicine Diponegoro University, Jl. Prof. H. Soedarto, SH Tembalang Semarang;

[3] Department of Microbiology, Faculty of Medicine, Diponegoro University, Semarang, IndonesiaAddress: Faculty of Medicine Diponegoro University, Jl. Prof. H. Soedarto, SH Tembalang Semarang;

关键词: brown algae;    diabetes mellitus;    MDA;    PCO;    Sargassum duplicatum;   

DOI  :  10.26532/sainsmed.v7i2.1172

来源: DOAJ

【 摘 要 】

Introduction: Brown algae (Sargassum duplicatum) contains bioactive compound with natural antioxidant that may potentially decrease lipid peroxidation and protein oxidation process in diabetes mellitus. Objective: to prove the effectiveness of brown algae extract administration (150mg/kgBW; 300mg/kgBW and 450 mg/kGBW respectively) in reducing serum MDA and PCO levels in streptozotocin-induced sprague dawley rat. Methods: This experiment study used the post test only control group design. Twenty eight (28) Sprague dawley rats induced with Streptozotocin (STZ) 40 mg/kgBW (i.p) were divided into four groups (n=7). The first group was diabetic non treated group (control). The second to fourth groups were the diabetic rats which given brown algae extract (150mg/kgBW; 300mg/kgBW and 450 mg/kgBW respectively) for 30 days. Serum MDA and PCO levels were examined by using ELISA method. Data were analyzed using one way ANOVA.Results: There were no significant differences in serum MDA levels among groups (p=0,405). However, serum PCO level in group administered with 450mg/kgBW of brown algae extract decreased significantly compared to control group (p=0.001), group administered with 150mg/kgBW (p=0.001) and 300mg/kgBW (p=0,037). Conclusion: Administration of brown algae extract did not decrease serum MDA levels significantly. Administration of 450mg/kgBW brown algae extract is effective to decrease serum PCO level significantly.

【 授权许可】

Unknown