Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study

Frontiers in Endocrinology

卷:12

Qian Zhang¹  Shuohua Chen²  Shouling Wu³  Runkuan Yang³  Yue Jiao⁴  Jie Xing⁴  Shutian Zhang⁴  Xiujing Sun⁴  Xiaoqian Ma⁴  Haiyun Shi⁴ 

[1] Clinical Epidemiology and EBM Unit, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, China;

[2] Department of Cardiology, Kailuan General Hospital, Tangshan, China;

[3] Department of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway;

[4] Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing, China;

关键词: serum uric acid;    body mass index;    mediation analysis;    metabolic syndrome;    nonalcoholic fatty liver disease;    obesity;   

DOI  :  10.3389/fendo.2021.657856

来源: DOAJ

【 摘 要 】

ObjectiveObesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid (SUA) and obesity are essential components of metabolic syndrome (MetS), it is uncertain whether the incidence of NAFLD results from serum uric acid, obesity, or other potential factors based on previous studies.Patients and methodsThis study enrolled 16,839 participants with no history of alcohol consumption and no fatty liver disease in 2010. All participants completed a survey which included health and lifestyle questionnaires, and underwent physical examination, ultrasonography, and laboratory examinations of blood samples. After the four-year follow up, 5,104 (30.31%) participants were diagnosed with NAFLD. The associations between SUA, BMI or obesity, and incident NAFLD were assessed by multivariate linear regression, logistic regression analysis, and mediation analysis, respectively.ResultsBy adjusting demographic and serum characteristics, linear correlation coefficients between obesity and SUA were 20.26 [95% confidence interval (CI)]: 15.74, 24.77), 13.31 (95% CI: 6.63, 19.99) and 22.21 (95% CI: 16.41, 28.02) in the total population, and in the female and male groups, respectively. The odds ratios were 2.49 (95% CI: 1.61, 3.87) in the total population, 5.71 (95% CI: 2.25, 14.45) in the female group and 1.99 (95% CI: 1.15, 3.45) in the male group for the correlation between obesity and incident NAFLD. The mediation analysis showed that SUA contributed to 10.03%, 0.58%, and 12.54% of obesity-related NAFLD development in the total population, females and males, respectively.ConclusionThe findings showed mediation linkages of both obesity and SUA with the incident NAFLD. The role of SUA as a mediator constitutes clinical significance that should be recognized and considered.

【 授权许可】

Unknown