Expression of activator protein-1 in papillary thyroid carcinoma and its clinical significance

World Journal of Surgical Oncology

卷:17

Zijian Feng¹  Qi Li¹  Zhen Liu¹  Cheng Xiao¹  Qiyuan Gao¹  Yonglian Huang¹ 

[1] Department of Pancreatic & Endocrine Surgery, Shengjing Hospital of China Medical University;

关键词: Activator protein-1;    Papillary thyroid carcinoma;    Immunohistochemistry;   

DOI  :  10.1186/s12957-019-1568-x

来源: DOAJ

【 摘 要 】

Abstract Background The abnormal expression of activator protein-1(AP-1) has recently been investigated in a variety of tumors. While the relationship between AP-1 and thyroid cancer is poorly studied, our study was to evaluate the protein expression and clinical value of AP-1 in papillary thyroid carcinoma (PTC). Methods The expression of AP-1 was examined by immunohistochemistry on paraffin-embedded tissues obtained from PTC and correspondent paracancerous tissues of 82 patients. Results Compared with paracancerous tissues, AP-1 expression was significantly elevated in PTC tissues and the positive rate was 79.3% (65/82). Our study found a linear trend relationship between the expression of AP-1 and tumor size. However, the differences in AP-1 expression among gender, age, lymph node metastasis, number of lesions, location of the lesion, and extrathyroid invasion are not statistically significant. Conclusions The expression of AP-1 plays an important role in the proliferation process of PTC.

【 授权许可】

Unknown