Hydrogen Sulfide-Releasing Fibrous Membranes: Potential Patches for Stimulating Human Stem Cells Proliferation and Viability under Oxidative Stress

International Journal of Molecular Sciences

卷:19

Sonia Melino¹  Matteo Ciocci²  Emilia Di Giovanni²  Ilaria Cacciotti³  Francesca Nanni⁴ 

[1] CIMER Center for Regenerative Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy;

[2] Department of Chemical Science and Technologies, University of Rome “Tor Vergata”, via della Ricerca Scientifica1, 00133 Rome, Italy;

[3] Department of Engineering, University of Rome “Niccolò Cusano”, via Don Carlo Gnocchi 3, 00166 Rome, Italy;

[4] Italian Interuniversity Consortium on Materials Science and Technology (INSTM), 50121 Florence, Italy;

关键词: PLA fibers;    organosulfur compounds;    garlic extracts;    mesenchymal stem cells;    microstructure;    thermal and mechanical properties;    cytotoxicity;    antibacterial properties;   

DOI  :  10.3390/ijms19082368

来源: DOAJ

【 摘 要 】

The design of biomaterial platforms able to release bioactive molecules is mandatory in tissue repair and regenerative medicine. In this context, electrospinning is a user-friendly, versatile and low-cost technique, able to process different kinds of materials in micro- and nano-fibers with a large surface area-to-volume ratio for an optimal release of gaseous signaling molecules. Recently, the antioxidant and anti-inflammatory properties of the endogenous gasotramsmitter hydrogen sulfide (H2S), as well as its ability to stimulate relevant biochemical processes on the growth of mesenchymal stem cells (MSC), have been investigated. Therefore, in this work, new poly(lactic) acid fibrous membranes (PFM), doped and functionalized with H2S slow-releasing donors extracted from garlic, were synthetized. These innovative H2S-releasing mats were characterized for their morphological, thermal, mechanical, and biological properties. Their antimicrobial activity and effects on the in vitro human cardiac MSC growth, either in the presence or in the absence of oxidative stress, were here assessed. On the basis of the results here presented, these new H2S-releasing PFM could represent promising and low-cost scaffolds or patches for biomedical applications in tissue repair.

【 授权许可】

Unknown