A Study of the Extended Lipid Profile including Oxidized LDL, Small Dense LDL, Lipoprotein (a) and Apolipoproteins in the Assessment of Cardiovascular Risk in Hypothyroid Patients

Journal of Clinical and Diagnostic Research

卷:10

Rakhee Yadav¹  Sanjiv Kumar Bansal² 

[1] Assistant Professor, Department of Biochemistry, SGT Medical College, Hospital and Research Institute, Budhera, Gurgaon, Haryana, India.;

[2] Associate Professor, Department of Biochemistry, SGT Medical College, Hospital and Research Institute, Budhera, Gurgaon, Haryana, India.;

关键词: apolipoprotein a;    apolipoprotein b;    coronary artery disease;    hypothyroidism;    oxidized;    small dense low density lipoprotein;   

DOI  :  10.7860/JCDR/2016/19775.8067

来源: DOAJ

【 摘 要 】

Introduction: Hypothyroidism is one of the most commonmetabolic disorders associated with dyslipidemia which posesa higher risk of Coronary Artery Disease (CAD) in such patients.Biochemical markers which can pick up the risk promptly arebecoming imperative now-a-days and thus the assessmentbeyond the conventional lipid profile is the need of the hour.Aims: To assess the association of non-conventional lipidparameters like small dense Low Density Lipoprotein (sd LDL),oxidized Low Density Lipoprotein (ox LDL), Apolipoprotein A(Apo A1), Apolipoprotein B (Apo B) and Lipoprotein (a) {Lp(a)}in hypothyroid patients and compare their values with theconventional lipid parameters such as Total Cholesterol (TC),Triglyceride (TG), Low-Density Lipoprotein Cholesterol (LDL-C)and High-Density Lipoprotein Cholesterol (HDL-C).Materials and Methods: One hundred and thirty clinically provenpatients of hypothyroidism aged 20-60 years and equal numberof age and gender matched healthy individuals were includedin this case control study. Serum sd LDL, ox LDL, Apo A1, ApoB, Lp (a), lipid profile, Thyroid Stimulating Hormone (TSH), FreeTriiodothyronine (FT3) and Free Tetraiodothyronine (FT4) levelswere measured in both the groups. The data was recorded andanalysed on SPSS system. The results of cases and controlswere compared by student t-test and one-way ANOVA. All theparameters were correlated with TSH by Pearson’s correlation.Results: We found significantly high levels of sd LDL, ox LDL,Apo B, Lp (a), TC, TG, LDL-C in cases as compared to thecontrols. Ox LDL has shown maximum correlation with serumTSH (p<0.0001, r=0.801) followed by sd LDL (p<0.0001, r=0.792),Apo B (p<0.001, r=0.783) and LDL-C (p<0.001, r=0.741).Moreover, ox LDL and sd LDL were found to be increased innormolipidemic hypothyroid patients thereby giving a strongsupportive evidence that estimation of these parameters canbecome fundamental in prompt identification of the high riskpatients of CAD in hypothyroid population.Conclusion: Non-conventional lipid parameters appear to bebetter markers for the assessment of cardiovascular risk inhypothyroidism and might help in the designing of the effectivetreatment protocols and areas of intervention by the cliniciansas well as researchers.

【 授权许可】

Unknown