Crohn’s Disease with Atypical Extra-Intestinal Manifestations Developing Under Treatment with Vedolizumab

European Journal of Case Reports in Internal Medicine

Michal Shteinberg¹  Shai Cohen¹  Yana Kogan²  Ori Sagol³  Aasem Abu Shtaya⁴ 

[1] Technion – Israel Institute of Technology, The B. Rappaport Faculty of Medicine, Haifa, Israel;

[2] Department of Internal Medicine “B”, Lady Davis Carmel Medical Center, Haifa, Israel;

[3] epartment of Internal Medicine “B”, Lady Davis Carmel Medical Center, Haifa, Israel;

关键词: crohn’s disease;    granuloma;    vedolizumab;    infliximab;   

DOI  :  10.12890/2021_002265

来源: DOAJ

【 摘 要 】

Crohn’s disease is a chronic inflammatory bowel disease that can affect any part of the GI tract, which is frequently associated with extra-intestinal manifestations. Pulmonary parenchymal disease is very uncommon and usually considered to be debilitating and harder to diagnose. Pulmonary granulomas are rarely described in the literature as a complication of Crohn’s disease. Here, we present a patient with Crohn’s disease exacerbation who developed granulomatous lung disease under treatment with vedolizumab. Our case may add evidence to the emerging theory that gut-selective biologic agents could lead to upregulation of some pro-inflammatory factors leading to the evolution of pulmonary disease.

【 授权许可】

Unknown