European Journal of Case Reports in Internal Medicine | |
Crohn’s Disease with Atypical Extra-Intestinal Manifestations Developing Under Treatment with Vedolizumab | |
Michal Shteinberg1  Shai Cohen1  Yana Kogan2  Ori Sagol3  Aasem Abu Shtaya4  | |
[1] Technion – Israel Institute of Technology, The B. Rappaport Faculty of Medicine, Haifa, Israel; | |
[2] Department of Internal Medicine “B”, Lady Davis Carmel Medical Center, Haifa, Israel; | |
[3] epartment of Internal Medicine “B”, Lady Davis Carmel Medical Center, Haifa, Israel; | |
关键词: crohn’s disease; granuloma; vedolizumab; infliximab; | |
DOI : 10.12890/2021_002265 | |
来源: DOAJ |
【 摘 要 】
Crohn’s disease is a chronic inflammatory bowel disease that can affect any part of the GI tract, which is frequently associated with extra-intestinal manifestations. Pulmonary parenchymal disease is very uncommon and usually considered to be debilitating and harder to diagnose. Pulmonary granulomas are rarely described in the literature as a complication of Crohn’s disease. Here, we present a patient with Crohn’s disease exacerbation who developed granulomatous lung disease under treatment with vedolizumab. Our case may add evidence to the emerging theory that gut-selective biologic agents could lead to upregulation of some pro-inflammatory factors leading to the evolution of pulmonary disease.
【 授权许可】
Unknown