Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis

Cells

卷:8

Jinglin Zhang¹  Yuhang Zhou¹  KaFai To¹  Wei Kang¹  PatrickM. K. Tang¹  Jun Yu²  AlfredS. L. Cheng³ 

[1] Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China;

[2] Institute of Digestive Disease, State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, China;

[3] School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China;

关键词: FGF;    FGFR;    gastric cancer;    monoclonal antibody;    small molecule;   

DOI  :  10.3390/cells8060637

来源: DOAJ

【 摘 要 】

Gastric cancer (GC) is one of the most wide-spread malignancies in the world. The oncogenic role of signaling of fibroblast growing factors (FGFs) and their receptors (FGFRs) in gastric tumorigenesis has been gradually elucidated by recent studies. The expression pattern and clinical correlations of FGF and FGFR family members have been comprehensively delineated. Among them, FGF18 and FGFR2 demonstrate the most prominent driving role in gastric tumorigenesis with gene amplification or somatic mutations and serve as prognostic biomarkers. FGF-FGFR promotes tumor progression by crosstalking with multiple oncogenic pathways and this provides a rational therapeutic strategy by co-targeting the crosstalks to achieve synergistic effects. In this review, we comprehensively summarize the pathogenic mechanisms of FGF-FGFR signaling in gastric adenocarcinoma together with the current targeted strategies in aberrant FGF-FGFR activated GC cases.

【 授权许可】

Unknown