Impact of vitamin E on redox biomarkers in non-alcoholic fatty liver disease

Redox Biology

卷:42

Jan Frank¹  Maren C. Podszun² 

[1] Department of Food Biofunctionality, Institute of Nutritional Sciences, University of Hohenheim, Germany;

[2] Corresponding author. University of Hohenheim, Institute of Nutritional Sciences, Department of Food Biofunctionality, Garbenstr. 28, 70599, Stuttgart, Germany.;

关键词: Hydroxyoctadecadienoic acid (HODE);    Lipid peroxidation biomarkers;    Non-alcoholic fatty liver disease (NAFLD);    Tocopherols;    Vitamin E;    4-Hydroxynonenal;   

DOI  :  

来源: DOAJ

【 摘 要 】

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western nations and characterized by excessive accumulation of lipids in the liver. In this narrative review, we summarize the evidence from human trials that free radical-induced oxidation of macromolecules, in particular of lipids, is a characteristic feature of NAFLD and non-alcoholic steatohepatitis (NASH). We further synthesize the data in the scientific literature describing the impact of vitamin E (mainly α-tocopherol) on concentrations of redox biomarkers in liver biopsies from patients with NAFLD as well as animal experiments. In summary, the available evidence from clinical trials suggests that reactive species-mediated damage to macromolecules, predominantly lipids, occurs in NAFLD and NASH and that daily supplementation with at least 200 I.U. α-tocopherol may alleviate oxidative stress in the liver of NAFLD patients. We propose α-tocopherol as a useful model substance to identify and validate suitable redox biomarkers that may be employed in future clinical trials of new therapeutics for NAFLD.

【 授权许可】

Unknown