Flakka: New Dangerous Synthetic Cathinone on the Drug Scene

International Journal of Molecular Sciences

卷:21

Kamil Kuca¹  Eugenie Nepovimova²  Blanka Klimova³  Martin Valis³  Jiri Patocka⁴  Wenda Wu⁵  Bingshu Zhao⁵ 

[1] Biomedical Research Centre, University Hospital, 50003 Hradec Kralove, Czech Republic;

[2] Department of Chemistry, Faculty of Science, University of Hradec Kralove, 50003 Hradec Kralove, Czech Republic;

[3] Department of Neurology of the Medical Faculty of Charles University and University Hospital in Hradec Kralove, Sokolska 581, 50005 Hradec Kralove, Czech Republic;

[4] Department of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia, 37005 Ceske Budejovice, Czech Republic;

[5] MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China;

关键词: Flakka;    bath salts;    synthetic cathinone;    α-pyrrolidinopentiophenone;   

DOI  :  10.3390/ijms21218185

来源: DOAJ

【 摘 要 】

New psychoactive substances are being used as drugs and appear to be quite popular nowadays. Thanks to their specific properties, these drugs create inimitable experiences for intoxicated people. Synthetic cathinones are the most common compounds in these new drugs. Among them, α-pyrrolidopentadione (α-PVP), or “Flakka” (street name), is one of the most famous cathinone-designed drugs. Similar to other synthetic cathinone drugs, α-PVP can effectively inhibit norepinephrine and dopamine transmitters. The adverse reactions of α-PVP mainly include mania, tachycardia, and hallucinations. An increasing number of people are being admitted to emergency wards due to the consequences of their use. This work mainly summarizes the history, synthesis, pharmacology, toxicology, structure–activity relationship, metabolism, clinical process and health risks, poisoning and death, forensic toxicology, and legal status of α-PVP. We hope this review will help bring more attention to the exploration of this substance in order to raise awareness of its negative impacts on humans.

【 授权许可】

Unknown