Surveillance of Antibacterial Usage during the COVID-19 Pandemic in England, 2020

Antibiotics

卷:10

the AMU COVID-19 Stakeholder Group¹  Berit Muller-Pebody²  Sarah Gerver²  Diane Ashiru-Oredope²  Emma L. Budd²  Susan Hopkins²  Aoife Hendrick²  Amelia Andrews²  Elizabeth Beech³ 

[1] ;

[2] Healthcare-Associated Infection and Antimicrobial Resistance Division, Public Health England, London NW9 5EQ, UK;

[3] NHS England and NHS Improvement, London SE1 6LH, UK;

关键词: antibacterials;    antibiotics;    COVID-19;    antimicrobial stewardship;   

DOI  :  10.3390/antibiotics10070841

来源: DOAJ

【 摘 要 】

Changes in antibacterial prescribing during the COVID-19 pandemic were anticipated given that the clinical features of severe respiratory infection syndrome caused by SARS-CoV-2 mirror bacterial respiratory tract infections. Antibacterial consumption was measured in items/1000 population for primary care and in Defined Daily Doses (DDDs)/1000 admissions for secondary care in England from 2015 to October 2020. Interrupted time-series analyses were conducted to evaluate the effects of the pandemic on antibacterial consumption. In the community, the rate of antibacterial items prescribed decreased further in 2020 (by an extra 1.4% per month, 95% CI: −2.3 to −0.5) compared to before COVID-19. In hospitals, the volume of antibacterial use decreased during COVID-19 overall (−12.1% compared to pre-COVID, 95% CI: −19.1 to −4.4), although the rate of usage in hospitals increased steeply in April 2020. Use of antibacterials prescribed for respiratory infections and broad-spectrum antibacterials (predominately ‘Watch’ antibacterials in hospitals) increased in both settings. Overall volumes of antibacterial use at the beginning of the COVID-19 pandemic decreased in both primary and secondary settings, although there were increases in the rate of usage in hospitals in April 2020 and in specific antibacterials. This highlights the importance of antimicrobial stewardship during pandemics to ensure appropriate prescribing and avoid negative consequences on patient outcomes and antimicrobial resistance.

【 授权许可】

Unknown